Standalone screen sand control method is one of the most commonly used sand control method for oil and gas wells. With the deepening of oil and gas field development, the working environment and its own conditions of the independent screen sand control system have changed. Affected by high temperature and high pressure, external load, corrosion, fluid erosion and other factors, it is easy to cause sand control failure, which seriously affects the normal production of oil and gas wells. In this paper, long?term mine practice and theoretical analysis are taken to investigate the reasons for sand control failure. It is considered that the main causes of sand control failure are sand control packer failure, sealing mechanism failure and sand control screen tube failure, among which sand control screen tube failure is the most likely to occur. Screen erosion, screen corrosion, geological factors and special operations are the main factors leading to the failure of sand control screen. Through the in?depth analysis of the causes of sand control failure in oil and gas wells, it provides an important basis for taking preventive measures to avoid sand control failure and affecting production.